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Ionis Reports Fourth Quarter and Full Year 2017 Financial Results
SPINRAZA launch one of the most successful in rare disease history
FY 2017 GAAP operating income of $25M; FY 2017 pro forma operating income of $111M
2017 year-end cash over $1B
Mid-2018 launches planned for inotersen and volanesorsen
Conference call and webcast today, February 27, 2018, at 11:30 a.m. Eastern Time

CARLSBAD, Calif., Feb. 27, 2018 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) today reported its financial results for the fourth quarter and full year 2017 and highlighted recent progress in advancing its business and drug pipeline.

Ionis Pharmaceuticals (PRNewsFoto/Ionis Pharmaceuticals, Inc.)

"In 2017, our accomplishments were remarkable. The historic launch of SPINRAZA and the acceptance of our regulatory filings for inotersen and volanesorsen, which set up potential launches of these two drugs in 2018, combined with our strong financial performance, demonstrate our ability to execute across all areas of our business. We also advanced our pipeline of novel drugs with positive data readouts from 11 clinical studies, including five with our LICA drugs, and introduced eight new drugs to the pipeline, further highlighting the broad capabilities and potential of our antisense technology platform," said Stanley T. Crooke, M.D., Ph.D., chairman of the board and chief executive officer.

"Looking ahead, we believe 2018 could be an important turning point for Ionis. Most important will be the launch of inotersen and volanesorsen, if approved. We also expect to report data from at least six Phase 2 studies, initiate at least five Phase 2 programs and report data from multiple proof-of-concept clinical studies. These important events build on our recent momentum, solidifying Ionis as a multi-product, commercial company delivering innovative antisense medicines to patients in need," continued Crooke. "As we advance our pipeline of antisense drugs and achieve important milestones in our collaborations, we expect to continue to provide substantial value to our shareholders and the patients we serve."

Financial Results and Highlights

  • Revenues for 2017 increased by more than 45%
    • For the fourth quarter and full year 2017, revenue was $172 million and $508 million, compared to $160 million and $347 million for the same periods in 2016.
    • Commercial revenue for 2017 was $113 million from SPINRAZA royalties and $9 million from other licensing and royalty payments. R&D revenue for 2017 was $386 million and increased by nearly 20% from 2016.
  • Operating income for 2017 increased by more than 150%, driven by strong revenues and reflecting prudent expense management
    • GAAP operating income was $25 million for 2017, compared to a GAAP operating loss of $46 million for the same period in 2016. Pro forma operating income was $111 million for 2017, compared to $26 million for the same period in 2016.
    • Operating expenses increased at a much slower rate than revenue with the increase primarily due to higher SG&A expenses as Ionis prepares to commercialize volanesorsen and inotersen this year.
  • Substantial cash position enabled pipeline progress
    • As of December 31, 2017, Ionis had cash, cash equivalents and short-term investments of more than $1 billion compared to $665 million at December 31, 2016. 
    • During 2017 Ionis received over $580 million in partner payments. Additionally, Ionis' cash balance at December 31, 2017 included proceeds from Akcea's 2017 IPO and Novartis' strategic investment in Akcea.

"2017 was our first year of commercial revenue in which we earned $113 million in SPINRAZA royalties. It was also our sixth consecutive year of revenue growth, driven by our focus on high-value, innovative drugs like SPINRAZA and multiple other exciting programs in our pipeline," said Elizabeth L. Hougen, chief financial officer of Ionis. "Our goal is to be a multi-product, sustainably profitable company. Consistent with this goal, we project 2018 will be our third consecutive year of pro forma operating profitability even as we prepare to launch two new drugs. For 2018, we are projecting R&D expenses of $360 million to $390 million and SG&A expenses of $180 million to $210 million both on a pro forma basis. We project that we will end 2018 with more than $800 million in cash."

All pro forma amounts referred to in this press release exclude non-cash compensation expense related to equity awards. Please refer to the reconciliation of pro forma and GAAP measures, which is provided later in this release.

Recent Pipeline and Technology Highlights

  • SPINRAZA for SMAone of the most successful orphan drug launches in history
    • SPINRAZA®, commercialized by Biogen, generated 2017 global sales of $884 million
    • Results from the ENDEAR study and CHERISH study, in which people with infantile-onset and later-onset SMA, respectively, were treated with SPINRAZA, were published in The New England Journal of Medicine
    • Prestigious 2017 Prix Galien USA Award for Best Biotechnology Product awarded to Ionis and Biogen for SPINRAZA
    • New collaboration with Biogen initiated to discover new antisense drugs with enhanced properties to treat SMA
  • Inotersen for hATTR – potential to transform the lives of people with hATTR
    • Marketing applications accepted, no FDA Advisory Committee recommended, Priority Review in the U.S. and Accelerated Assessment in the EU
    • Preparations for global launch, planned for mid-2018, progressing
    • Phase 3 NEURO-TTR study met both primary endpoints demonstrating benefit compared to placebo in multiple measures of quality of life and disease severity; 50% of inotersen-treated patients experienced improvement from baseline in quality of life
  • Volanesorsen for FCS and FPL – potential first treatment for people with FCS
    • Marketing applications accepted in the U.S., EU and Canada with Promising Innovative Medicine designation in the UK and Priority Review in Canada
    • Preparations for global launch for FCS, planned for mid-2018, progressing
    • Phase 3 APPROACH study met primary endpoint of reducing triglyceride levels in people with FCS
  • Pipeline Programs (early and mid-stage)advancing wholly owned and partnered programs
    • Positive results from seven Phase 2 studies reported, including:
      • Positive data from Phase 1/2 study of IONIS-STAT3-2.5Rx in combination with AstraZeneca's Imfinzi reported for people with head and neck cancer
      • Robust, dose-dependent reductions of mHTT observed in people with Huntington's disease treated with IONIS-HTTRx 
    • Positive clinical data on five LICA drugs reported, demonstrating consistent, positive performance and sustained target reduction with potential for monthly or less frequent dosing
    • Positive results from six Phase 1 studies reported
    • Nine Phase 2 studies and four Phase 1 studies initiated across multiple therapeutic areas to treat people with both broad and rare diseases

"In 2017, we and our partners advanced key programs in all of our therapeutic areas, including cardiometabolic, oncology, neurology, and severe and rare disease. Of the eight new drugs we added to the pipeline, six were drugs that use our more potent LICA technology or Generation 2.5 chemistry, and two were drugs to treat neurodegenerative disorders. We also added to our pipeline our second orally delivered, locally acting drug for a GI autoimmune disease. These achievements demonstrate the success of our wholly owned and partnered programs," said Brett P. Monia, Ph.D., chief operating officer and senior vice president of antisense drug discovery and translational medicine at Ionis Pharmaceuticals. "Looking ahead, we plan to pursue only those partnerships with infrastructure and resources that complement our own. Simultaneously, we plan to continue to build our wholly owned pipeline of drugs to treat patients with rare and serious diseases."

Expected Events Through Mid-2018

  • Launch of inotersen for people with hATTR, if approved
  • Launch of volanesorsen for people with FCS, if approved
  • Report results from five Phase 2 programs, including data from studies with IONIS-HTTRx in people with Huntington's disease and data from a 6-12 month study with AKCEA-APO(a)-LRx in people with high Lp(a) and cardiovascular disease
  • Initiate up to six Phase 2 or Phase 3 studies and three Phase 1 studies, including the initiation of a clinical study with follow-on LICA drug, IONIS-TTR-LRx

Revenue

Ionis' revenue for the fourth quarter and full year 2017 was $172.3 million and $507.7 million, compared to $160.3 million and $346.6 million for the same periods in 2016. Ionis' revenue in 2017 consisted of the following:

Commercial Revenue:

  • $113 million from SPINRAZA royalties; and
  • $9 million from other licensing and royalty payments.

R&D Revenue: 

  • $118 million in milestone payments from Biogen, including $90 million in milestone payments for SPINRAZA, $15 million for validating two undisclosed neurological disease targets and $10 million for initiating a Phase 1/2 study of IONIS-MAPTRx;
  • $65 million from Bayer for the license of IONIS-FXI-LRx;
  • $48 million from Roche primarily for the license of IONIS-HTTRx;
  • $10 million from Janssen for license of IONIS-JBI2-2.5Rx and initiation of Phase 1 study of IONIS-JBI1-2.5Rx;
  • $115 million from the amortization of upfront fees; and
  • $30 million from services Ionis performed for its partners, of which more than half related to manufacturing services.

Ionis' R&D revenue may fluctuate quarterly based on the nature and timing of payments under agreements with its partners and consists primarily of revenue from the amortization of upfront fees, milestone payments and license fees.

At the beginning of 2018, Ionis adopted the new revenue recognition accounting standard on a retrospective basis, which means that starting with the first quarter, Ionis will begin showing all periods presented using the new standard. The Company does not anticipate that there will be a significant impact to its previously reported revenue. Under the new standard, Ionis' revenue for 2017 will increase by approximately 3%.

Operating Expenses

Operating expenses for the fourth quarter and full year 2017 on a GAAP basis were $174.0 million and $483.1 million, respectively, and on a pro forma basis were $151.7 million and $397.2 million, respectively. This is compared to GAAP operating expenses of $119.2 million and $392.9 million and pro forma operating expenses of $104.0 million and $320.8 million for the same periods in 2016. Operating expenses increased in 2017, compared to 2016, principally due to higher SG&A expenses as Ionis prepares to commercialize volanesorsen and inotersen in 2018. The Company's SG&A expenses also increased in 2017 compared to 2016 because of fees it owes under its in-licensing agreements related to SPINRAZA.

Net Income (Loss)

Ionis reported a net loss of $4.7 million and $17.3 million for the fourth quarter and full year 2017, respectively, compared to net income of $25.9 million and a net loss of $86.6 million for the same periods in 2016, all according to GAAP. On a pro forma basis, Ionis reported net income of $17.7 million and $68.7 million for the fourth quarter and full year 2017, respectively, compared to net income of $41.0 million and a net loss of $14.4 million for the same periods in 2016. Ionis' GAAP and pro forma net loss improved for 2017 compared to 2016 primarily due to the addition of commercial revenue from SPINRAZA royalties and increased R&D revenue.

Additionally, in 2017, Ionis recorded two non-cash, non-recurring items in other expenses, which contributed to the Company's net loss. These two items were the previously capitalized fair value of the potential premium Ionis would have received from Novartis if Akcea had not completed its IPO and the loss the Company recognized on the purchase of its primary R&D facility. In 2016, Ionis recorded a $4.0 million non-cash loss related to the early repurchase of its 2¾ percent convertible senior notes, which contributed to the Company's net loss for 2016.

Net Loss Attributable to Noncontrolling Interest in Akcea Therapeutics, Inc.

Akcea sold shares of its common stock to third parties in its IPO in July 2017. From the closing of the IPO through the end of 2017, Ionis owned 68 percent of Akcea. The shares held by third parties represent an interest in Akcea's equity that Ionis does not control. However, because Ionis continues to maintain overall control of Akcea through its voting interest, Ionis reflects the assets, liabilities and results of operations of Akcea in Ionis' consolidated financial statements. Ionis reflects the noncontrolling interest attributable to other holders of Akcea's common stock in a separate line called "Net loss attributable to noncontrolling interest in Akcea" on Ionis' statement of operations. Ionis' net loss attributable to noncontrolling interest in Akcea for the fourth quarter and full year 2017 was $7.4 million and $11.3 million, respectively. Ionis also added a corresponding account in its stockholders' equity section on its balance sheet called "Noncontrolling interest in Akcea Therapeutics, Inc."  

Net Income (Loss) Attributable to Ionis Common Stockholders

Ionis reported net income attributable to Ionis' common stockholders of $2.7 million for the fourth quarter of 2017, compared to $25.9 million for the same period in 2016. For the full years 2017 and 2016, Ionis reported a net loss attributable to Ionis' common stockholders of $6.0 million and $86.6 million, respectively. For the fourth quarter of 2017, basic and diluted net income per share were $0.02 compared to basic and diluted net income per share of $0.21 for the same period in 2016. For the full year 2017, basic and diluted net income per share were $0.08 compared to basic and diluted net loss per share of $0.72 for the same period in 2016.

Webcast and Conference Call

Today, at 11:30 a.m. Eastern Time, Ionis will conduct a live webcast conference call to discuss this earnings release and related activities. Interested parties may listen to the call by dialing 877-443-5662 or access the webcast at www.ionispharma.com. A webcast replay will be available for a limited time.

ABOUT IONIS PHARMACEUTICALS

Ionis is the leading company in RNA-targeted drug discovery and development focused on developing drugs for patients who have the highest unmet medical needs, such as those patients with severe and rare diseases. Using its proprietary antisense technology, Ionis has created a large pipeline of first-in-class or best-in-class drugs, with over three dozen drugs in development. SPINRAZA® (nusinersen) has been approved in global markets for the treatment of spinal muscular atrophy (SMA). Biogen is responsible for commercializing SPINRAZA. Drugs that have successfully completed Phase 3 studies include inotersen, an antisense drug Ionis is developing to treat patients with hereditary TTR amyloidosis (hATTR), and volanesorsen, an antisense drug discovered by Ionis and co-developed by Ionis and Akcea Therapeutics to treat patients with familial chylomicronemia syndrome or familial partial lipodystrophy. Akcea, an affiliate of Ionis, is a biopharmaceutical company focused on developing and commercializing drugs to treat patients with serious cardiometabolic diseases caused by lipid disorders. If approved, volanesorsen will be commercialized through Ionis' affiliate, Akcea. Inotersen filings for marketing approval have been submitted in the U.S. and EU. Volanesorsen filings for marketing approval have been submitted in the U.S., EU, and Canada. Ionis' patents provide strong and extensive protection for its drugs and technology. Additional information about Ionis is available at www.ionispharma.com.

IONIS PHARMACEUTICALS' FORWARD-LOOKING STATEMENT

This press release includes forward-looking statements regarding Ionis' business, financial guidance and the therapeutic and commercial potential of SPINRAZA, inotersen, volanesorsen and Ionis' technologies and products in development, including the business of Akcea Therapeutics, Inc., Ionis' majority owned subsidiary. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2016, and its most recent quarterly report on Form 10-Q, which are on file with the SEC. Copies of these and other documents are available from the Company.

In this press release, unless the context requires otherwise, "Ionis," "Company," "we," "our," and "us" refers to Ionis Pharmaceuticals and its subsidiaries.

Ionis Pharmaceuticals™ is a trademark of Ionis Pharmaceuticals, Inc. Akcea Therapeutics™ is a trademark of Ionis Pharmaceuticals, Inc. SPINRAZA® is a registered trademark of Biogen.

IONIS PHARMACEUTICALS, INC.

SELECTED FINANCIAL INFORMATION

Condensed Consolidated Statements of Operations

(In Thousands, Except Per Share Data)

 
   

Three months ended,

 

Year ended,

 
   

December 31,

 

December 31,

 
   

2017

 

2016

 

2017

 

2016

 

Revenue:

 

(unaudited)

     

     Commercial revenue:

                 

SPINRAZA royalties

 

$52,073

 

$         883

 

$112,540

 

$          883

 

Licensing and royalty revenue

 

4,537

 

150

 

9,519

 

19,839

 

Total commercial revenue

 

56,610

 

1,033

 

122,059

 

20,722

 

    Research and development revenue under collaborative agreements

 

115,689

 

159,316

 

385,607

 

325,898

 

Total revenue

 

172,299

 

160,349

 

507,666

 

346,620

 

Expenses:

                 

    Research, development and patent expenses

 

128,285

 

101,151

 

374,644

 

344,320

 

    Selling, general and administrative

 

45,707

 

18,043

 

108,488

 

48,616

 

Total operating expenses

 

173,992

 

119,194

 

483,132

 

392,936

 

Income (loss) from operations

 

(1,693)

 

41,155

 

24,534

 

(46,316)

 

Other income (expense):

                 

Investment income

 

654

 

1,561

 

8,179

 

5,472

 

Interest expense

 

(10,787)

 

(9,934)

 

(44,752)

 

(38,795)

 

Loss on extinguishment of financing liability for leased facility

 

-

 

(3,983)

 

(7,689)

 

(3,983)

 

Other expenses

 

-

 

-

 

(3,548)

 

-

 

Income (loss) before income tax benefit (expense)

 

(11,826)

 

28,799

 

(23,276)

 

(83,622)

 
                   

Income tax benefit (expense)

 

7,164

 

(2,934)

 

5,980

 

(2,934)

 
                   

Net income (loss)

 

(4,662)

 

25,865

 

(17,296)

 

(86,556)

 

Net loss attributable to noncontrolling interest in Akcea Therapeutics, Inc.

 

7,406

 

-

 

11,326

 

-

 

Net income (loss) attributable to Ionis Pharmaceuticals, Inc. common stockholders

 

$2,744

 

$25,865

 

$(5,970)

 

$(86,556)

 
                   

Basic net income (loss) per share

 

$0.02

 

$0.21

 

$0.08

 

$(0.72)

 

Diluted net income (loss) per share

 

$0.02

 

$0.21

 

$0.08

 

$(0.72)

 

Shares used in computing basic net income (loss) per share

 

124,818

 

121,340

 

124,016

 

120,933

 

Shares used in computing diluted net income (loss) per share

 

126,862

 

123,953

 

126,098

 

120,933

 

 

IONIS PHARMACEUTICALS, INC.

Reconciliation of GAAP to Pro Forma Basis:

Condensed Consolidated Operating Expenses, Income (Loss) From Operations, and Net Income (Loss)

(In Thousands)

 
   

Three months ended,

December 31,

 

Year ended,

December 31,

   

2017

 

2016

 

2017

 

2016

   

(unaudited)

   

As reported operating expenses according to GAAP

 

$173,992

 

$119,194

 

$483,132

 

$392,936

    Excluding compensation expense related to equity awards      

 

(22,333)

 

(15,158)

 

(85,975)

 

(72,108)

Pro forma operating expenses

 

$151,659

 

$104,036

 

397,157

 

$320,828

                 

As reported income (loss) from operations according to GAAP

 

$(1,693)

 

$41,155

 

$24,534

 

$(46,316)

Excluding compensation expense related to equity awards

 

(22,333)

 

(15,158)

 

(85,975)

 

(72,108)

Pro forma income (loss) from operations

 

$20,640

 

$56,313

 

$110,509

 

$25,792

 

As reported net income (loss) attributable to Ionis Pharmaceuticals, Inc. common stockholders according to GAAP

 

$2,744

 

$25,865

 

$(5,970)

 

$(86,556)

Excluding compensation expense related to equity awards

 

(22,333)

 

(15,158)

 

(85,975)

 

(72,108)

Pro forma net income (loss) attributable to Ionis Pharmaceuticals, Inc. common stockholders

 

$25,077

 

$41,023

 

$80,005

 

$(14,448)

Reconciliation of GAAP to Pro Forma Basis

As illustrated in the Selected Financial Information in this press release, pro forma operating expenses, pro forma income (loss) from operations, and pro forma net income (loss) were adjusted from GAAP to exclude compensation expense related to equity awards, which are non-cash. Ionis has regularly reported non-GAAP measures for operating results as pro forma results. These measures are provided as supplementary information and are not a substitute for financial measures calculated in accordance with GAAP. Ionis reports these pro forma results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows. Further, the presentation of Ionis' pro forma results is consistent with how Ionis' management internally evaluates the performance of its operations.

IONIS PHARMACEUTICALS, INC.

Condensed Consolidated Balance Sheets

(In Thousands)

   
           
   

December 31,

 

December 31,

 
   

2017

 

2016

 
           

Assets:

         

  Cash, cash equivalents and short-term investments

 

$1,022,715

 

$665,223

 

  Contracts receivable

 

62,955

 

108,043

 

  Other current assets

 

82,314

 

24,666

 

  Property, plant and equipment, net

 

121,907

 

92,845

 

  Other assets

 

32,133

 

21,690

 

     Total assets

 

$1,322,024

 

$912,467

 
           

Liabilities and stockholders' equity:

         

  Other current liabilities

 

$118,276

 

$82,504

 

  Current portion of deferred contract revenue

 

106,465

 

51,280

 

  1% convertible senior notes

 

533,111

 

500,511

 

  Long-term obligations, less current portion

 

72,745

 

87,409

 

  Long-term deferred contract revenue

 

72,708

 

91,198

 

  Total Ionis stockholders' equity

 

330,872

 

99,565

 

  Noncontrolling interest in Akcea Therapeutics, Inc.

 

87,847

 

-

 

  Total stockholders' equity

 

418,719

 

99,565

 

    Total liabilities and stockholders' equity

 

$1,322,024

 

$912,467

 
             

 

IONIS PHARMACEUTICALS, INC.

SELECTED FINANCIAL INFORMATION

Condensed Consolidating Statement of Operations

(In Thousands)

 
   

Year ended,
December 31, 2017

   

Ionis

 

Akcea

 

Eliminations

 

Ionis Consolidated

Revenue:

   

     Commercial revenue:

               

SPINRAZA royalties

 

$112,540

 

$-

 

$-

 

$112,540

Licensing and royalty revenue

 

9,519

 

-

 

-

 

9,519

Total commercial revenue

 

122,059

 

-

 

-

 

122,059

    Research and development revenue under collaborative agreements

 

330,398

 

55,209

 

-

 

385,607

    Intercompany revenue

 

54,407

 

-

 

(54,407)

 

-

Total revenue

 

506,864

 

55,209

 

(54,407)

 

507,666

Expenses:

               

    Research, development and patent expenses

 

302,281

 

126,890

 

(54,527)

 

374,644

    Selling, general and administrative

 

71,507

 

36,981

     

108,488

 

Total operating expenses

 

373,788

 

163,871

 

(54,527)

 

483,132

Income (loss) from operations

 

133,076

 

(108,662)

 

120

 

24,534

Other income (expense):

               

Investment income

 

8,097

 

1,813

 

(1,731)

 

8,179

Interest expense

 

(44,752)

 

(1,731)

 

1,731

 

(44,752)

Loss on extinguishment of financing liability for leased facility

 

(7,689)

 

-

 

-

 

(7,689)

Other expenses

 

(3,652)

 

104

 

-

 

(3,548)

Income (loss) before income tax benefit (expense)

 

85,080

 

(108,476)

 

120

 

(23,276)

                 

Income tax benefit (expense)

 

7,255

 

(1,275)

 

-

 

5,980

                 

Net income (loss)

 

92,335

 

(109,751)

 

120

 

(17,296)

Net loss attributable to noncontrolling interest in Akcea Therapeutics, Inc.

 

-

 

-

 

11,326

 

11,326

Net income (loss) attributable to Ionis Pharmaceuticals, Inc. common stockholders

 

$92,335

 

$(109,751)

 

$11,446

 

$(5,970)

 

 

 

IONIS PHARMACEUTICALS, INC.

Condensed Consolidating Balance Sheet

(In Thousands)

 
   

December 31, 2017

               

Ionis

   

Ionis

 

Akcea

 

Eliminations

 

 Consolidated

                 

Assets:

               

  Cash, cash equivalents and short-term investments

 

$762,585

 

 

$260,130

 

$-

 

$1,022,715

  Contracts receivable

 

$57,542

 

5,413

 

-

 

62,955

  Receivable from Akcea Therapeutics, Inc.

 

14,365

 

-

 

(14,365)

 

-

  Other current assets

 

81,012

 

1,302

 

-

 

82,314

  Property, plant and equipment, net

 

121,830

 

77

 

-

 

121,907

  Other assets

 

304,494

 

1,882

 

(274,243)

 

32,133

     Total assets

 

$1,341,828

 

$268,804

 

$(288,608)

 

$1,322,024

                 

Liabilities and stockholders' equity:

               

  Other current liabilities

 

$102,367

 

$30,274

 

$(14,365)

 

$118,276

  Current portion of deferred contract revenue

 

55,886

 

50,579

 

-

 

106,465

  1% convertible senior notes

 

533,111

 

-

 

-

 

533,111

  Long-term obligations, less current portion

 

72,733

 

12

 

-

 

72,745

  Long-term deferred contract revenue

 

66,101

 

8,306

 

(1,699)

 

72,708

  Total stockholders' equity before noncontrolling interest

 

511,630

 

179,633

 

(360,391)

 

330,872

  Noncontrolling interest in Akcea Therapeutics, Inc.

 

-

 

-

 

87,847

 

87,847

  Total stockholders' equity

 

511,630

 

179,633

 

(272,544)

 

418,719

    Total liabilities and stockholders' equity

 

$1,341,828

 

$268,804

 

$(288,608)

 

$1,322,024

 

 

SPINRAZA 2017 Patient Dynamics

 

US Patient Dynamics*

Q1:17

Q2:17

Q3:17

Q4:17

Total patients

210

710

1,240

1,650

New patient starts

210

500

530

420

Average doses per patient

2.3

2.5

1.8

1.5

% Loading doses

100%

100%

90%

75%

% Maintenance doses

0%

0%

10%

25%

% Free doses

25%

20%

20%

20%

 

*As announced by Biogen in their Q4:17 earnings call

 

 

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SOURCE Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals Investor and Media Contacts: D. Wade Walke, Ph.D., Vice President, Corporate Communications and Investor Relations, 760-603-2741

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