Press Releases
Isis Initiates Phase 1 Study in Patients With Cancer With the First Generation 2.5 Antisense Drug, ISIS-STAT3Rx
"The role of STAT3 as a key factor critical for tumor cell growth and survival of cancer cells has made STAT3 widely viewed as an important target of interest," said
"We and many others are very interested in STAT3 as a therapeutic target because of the important role STAT3 plays in the survival and growth of difficult to treat cancers. The marked improvements in potency of our Generation 2.5 antisense drugs that we have seen in cancer models cause us to believe that these drugs could have a profound impact in treating cancer," said
ISIS-STAT3Rx is the first Generation 2.5 drug in Isis' pipeline. It is designed to treat cancer by inhibiting the production of STAT3, a gene that blocks natural cell death and that is critical for tumor cell growth and survival. Inhibition of STAT3 has been shown to block the induction of tumor-associated cytokines involved in the progression of cancer, such as IL-6, IL-1, TGFβ, and IL-10, which could serve as important biomarkers in clinical studies. Analyses of these cytokines in Phase 1 could serve as an early indicator of anticancer activity of ISIS-STAT3Rx in patients with cancer.
ABOUT
Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners. Isis' broad pipeline consists of 26 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, and cancer. Isis' partner, Genzyme, plans to commercialize Isis' lead product, KYNAMRO, following regulatory approval, which is expected in 2012. Isis' patents provide strong and extensive protection for its drugs and technology. Additional information about Isis is available at www.isispharm.com.
This press release includes forward-looking statements regarding the discovery, development, activity, therapeutic potential and safety of ISIS-STAT3Rx and the therapeutic benefit of antisense drugs that incorporate Isis' Generation 2.5 chemistry. Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs, including the planned commercialization of KYNAMRO, is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Isis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Isis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Isis' programs are described in additional detail in Isis' annual report on Form 10-K for the year ended
In this press release, unless the context requires otherwise, "Isis," "Company," "we," "our," and "us" refers to
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SOURCE
Kristina Lemonidis, Director, Investor Relations, +1-760-603-2490, or Amy Blackley, Ph.D., Assistant Director, Corporate Communications, +1-760-603-2772