Investor FAQ

If you are interested in Ionis Pharmaceuticals' investment details, you can find the answers to some frequently asked questions below.

1.Where are you located?
2.Can you provide a brief description of your Company?
3.When was the Company founded and when did it go public?
4.What is Ionis stock symbol and on what exchange is it traded?
5.How many shares are outstanding?
6.How can I purchase shares?
7.How can I get a copy of your annual report?
8.I have lost my stock certificates. How can I replace them?
1.Where are you located?
 Ionis Pharmaceuticals, Inc.
2855 Gazelle Court
Carlsbad, CA 92010
(Carlsbad is approximately 35 miles north of downtown San Diego.)

2.Can you provide a brief description of your Company?
 Ionis is the leading company in RNA-targeted drug discovery and development focused on developing drugs for patients who have the highest unmet medical needs, such as those patients with severe and rare diseases.  Using its proprietary antisense technology, Ionis has created a large pipeline of first-in-class or best-in-class drugs, with over a dozen drugs in mid- to late-stage development.  Drugs currently in Phase 3 development include volanesorsen, a drug Ionis is developing and plans to commercialize through its wholly owned subsidiary, Akcea Therapeutics, to treat patients with either familial chylomicronemia syndrome or familial partial lipodystrophy; IONIS-TTRRx, a drug Ionis is developing with GSK to treat patients with TTR amyloidosis; and SPINRAZA (nusinersen), a drug Ionis is developing with Biogen to treat infants and children with spinal muscular atrophy.  Ionis’ patents provide strong and extensive protection for its drugs and technology.  Additional information about Ionis is available at www.ionispharma.com.

3.When was the Company founded and when did it go public?
 Ionis Pharmaceuticals, Inc. was founded in 1989. Ionis conducted its initial public offering two years later in 1991.

4.What is Ionis stock symbol and on what exchange is it traded?
 Ionis is traded on the NASDAQ stock exchange under the symbol IONS. Please note that prior to December 22, 2015 our symbol was ISIS and prior to February 21, 2002 our symbol was ISIP.

5.How many shares are outstanding?
 The number of shares of voting common stock outstanding as of November 2, 2016 was 121,202,967.

6.How can I purchase shares?
 To purchase Ionis stock you may use the broker of your choice. Ionis does not offer a direct stock purchase plan.

7.How can I get a copy of your annual report?
 To view a PDF file of the annual reports from 2013-2015 click here. If you would like to receive a hard copy of any of Ionis' annual reports, please click here. Please note that if you are requesting that we send the annual report to an address outside of the U.S. (including Canada and Mexico) you must include your telephone number. The US Postal Service requires a phone number for shipments out of the U.S.

8.I have lost my stock certificates. How can I replace them?
 Contact our Transfer Agent, American Stock Transfer & Trust Company:

American Stock Transfer & Trust Company (AST)
59 Maiden Lane
Plaza Level
New York, NY 10038
ATTN: Shareholder Services
Tel 1-800-937-5449
Tel 1-718-921-8206
http://www.amstock.com/main/

To begin the process, click here:
https://secure.amstock.com/shareholder/sh_login.asp