Corporate Governance - Committee Composition

Below is a summary of our committee structure and membership information. To read more about any of the committees, click on committee names in the chart below.
Chairperson Chairperson Committee Member Member Financial Expert Financial Expert
Audit CommitteeNominating, Governance & Review CommitteeCompensation CommitteeScience/ MedicalAgenda
Outside Directors
Spencer R. Berthelsen, M.D. 
Spencer R. Berthelsen, M.D.
Chairman and Managing Director, Kelsey-Seybold Clinic


Dr. Berthelsen has served as a Director of Ionis since May 2002. Since 1980, he has practiced Internal Medicine with the Kelsey Seybold Clinic, a 400 physician medical group based in the Texas Medical Center in Houston. Dr. Berthelsen has served in various senior leadership positions at Kelsey Seybold, including Chairman of the Department of Internal Medicine, Medical Director and Managing Director. He served as Chairman of their Board of Directors from October 2001 through April 2016. He has... 
  Chairperson Chairperson Committee Member  
Breaux Castleman 
Breaux Castleman
President and Chief Executive Officer, Syntiro Healthcare Services, Inc.


Mr. Castleman has served as a Director of Ionis since June 2013. Since August 2001, Mr. Castleman has been president and chief executive officer of Syntiro Healthcare Services, Inc., a healthcare investment company, which sold its operations as a service provider of integrated care management and disease management. Mr. Castleman was a director of USMD Holdings, Inc., a physician-led integrated healthcare system, from September 2009 until October 2016 and was a director of MELA Sciences, Inc.... 
Committee Member     
Joseph Klein, III 
Joseph Klein, III
Managing Director, Gauss Capital Advisors, LLC


Mr. Klein has served as a Director of Ionis since December 2005. Mr. Klein is currently Managing Director of Gauss Capital Advisors, LLC, a financial consulting and investment advisory firm focused on biopharmaceuticals, which he founded in March 1998. From September 2003 to December 2008, Mr. Klein also served as a Venture Partner of Red Abbey Venture Partners, L.P., a life science private equity fund. From September 2001 to September 2002, Mr. Klein was a Venture Partner of MPM Capital, a h... 
Committee Member     
Joseph Loscalzo, M.D., Ph.D. 
Joseph Loscalzo, M.D., Ph.D.
Head of Department of Medicine and Physician-in-Chief, Brigham & Woman's Hospital, Harvard Medical School


Dr. Loscalzo is Hersey Professor of the Theory and Practice of Medicine at Harvard Medical School, Chairman of the Department of Medicine, and Physician-in-Chief at Brigham and Women’s Hospital. Dr. Loscalzo received his A.B. degree, summa cum laude, his Ph.D. in biochemistry, and his M.D. from the University of Pennsylvania. His clinical training was completed at Brigham and Women’s Hospital and Harvard Medical School, where he served as Resident and Chief Resident in medicine and Fellow in ... 
  Committee Member   Committee Member Committee Member
Frederick T. Muto, Esq.* 
Frederick T. Muto, Esq.*
Partner, Cooley LLP


Mr. Muto has served as a Director of Ionis since March 2001. Mr. Muto joined the law firm of Cooley LLP, outside counsel to Ionis, in 1980 and became a partner in 1986. He is a founding partner of Cooley LLP’s San Diego office and was Chair of the firm’s Business Department. ... 
     Committee Member
Joseph H. Wender Financial Expert
Joseph H. Wender
Senior Consultant, Goldman Sachs & Co.


Mr. Wender has served as a Director of Ionis since January 1994. Mr. Wender began with Goldman, Sachs & Co. in 1971 and became a General Partner of that firm in 1982, where he headed the Financial Institutions Group for over a decade. Since January 2008, he has been a Senior Consultant to Goldman Sachs & Co. He is also an Independent Trustee of the Schwab Family of Funds and Director of Grandpoint Capital, a bank holding company. Mr. Wender also is a managing partner and owns, with his wife,... 
Chairperson Committee Member Committee Member   
Inside Directors
Stanley T. Crooke, M.D., Ph.D.  
Stanley T. Crooke, M.D., Ph.D.
Chairman of the Board and Chief Executive Officer, Ionis Pharmaceuticals, Inc.


Dr. Crooke is founder, chairman, and chief executive officer of Ionis Pharmaceuticals. During his tenure at Ionis, he has led the scientific development of a new platform for drug discovery, antisense technology and engineered the creation of one of the largest and more advanced development pipelines in the biotechnology industry. Currently, Ionis has more than 38 drugs in development including several drugs in phase 3 and a larger number in phase 2 clinical trials.

Ionis ha... 

    Chairperson Chairperson
B. Lynne Parshall, Esq. 
B. Lynne Parshall, Esq.
Director and Chief Operating Officer, Ionis Pharmaceuticals, Inc.


Ms. Parshall is Director and Chief Operating Officer of Ionis Pharmaceuticals. She is responsible for overseeing the operations of finance, legal, patents, manufacturing, information technology, regulatory and alliance management, health and safety, facilities, corporate communications, and business and corporate development. Ms. Parshall joined Ionis in November 1991.

Previously, Ms. Parshall was a Partner with the firm of Cooley Godward LLP, now Cooley LLP, where she represented sev... 

     Committee Member

* Mr. Frederick T. Muto, Esq. serves as counsel to the Compensation Committee and Nominating, Governance and Review Committee.