Deutsche Bank AG
Taunusanlage 12, D-60325
Frankfurt am Main
Federal Republic of Germany



Jeffrey A. Ruiz
Vice President
Telephone: (212) 469-3667


                                          February 13, 2003


Securities and Exchange Commission
SEC Document Control
450 Fifth Street, N.W.
Washington, DC  20549
Attn:  Filing Desk


Dear Sir or Madame:

 Re:  Filing of Schedule 13G - Isis Pharmaceuticals Incorporated




 Pursuant to Rule 13d-1 of the Securities Exchange Act of 1934, attached is one
copy of Schedule 13G with respect to the common stock of the above referenced
corporation.

Please acknowledge your receipt of the Schedule 13G by return e-mail
confirmation.

                                          Sincerely,



                                          Jeffrey A. Ruiz





Enclosures


<PAGE>


                                     UNITED STATES
                          SECURITIES AND EXCHANGE COMMISSION
                                  Washington, D.C. 20549

                                      SCHEDULE 13G
                                    (Amendment No. )

                  Under the Securities Exchange Act of 1934

                       Isis Pharmaceuticals Incorporated
                     ---------------------------------------
                                  NAME OF ISSUER:


                          Common Stock ($0.001 Par Value)
                     ---------------------------------------
                           TITLE OF CLASS OF SECURITIES

                                   464330109
                     ---------------------------------------
                                 CUSIP NUMBER


                                December 31, 2002
                     ---------------------------------------
                (Date of Event Which Requires Filing of this Statement)


         Check the appropriate box to designate the rule pursuant to which this
         Schedule is filed:

                  [X] Rule 13d-1(b)

                  [   ]Rule 13d-1(c)

                  [   ]Rule 13d-1(d)




<PAGE>






1. NAME OF REPORTING PERSONS
    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

         Deutsche Bank AG*

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
                (A) [ ]
                (B) [ ]

3.       SEC USE ONLY

4.       CITIZENSHIP OR PLACE OF ORGANIZATION

    Federal Republic of Germany

NUMBER OF         5.       SOLE VOTING POWER
SHARES                     2,671,747
BENEFICIALLY      6.       SHARED VOTING POWER
OWNED BY                   9,999
EACH              7.       SOLE DISPOSITIVE POWER
REPORTING                  2,909,918
PERSON WITH       8.       SHARED DISPOSITIVE POWER
                           223,500

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         3,133,418

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
      SHARES [ ]

11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

        5.7%

12. TYPE OF REPORTING PERSON

         HC, CO, BK

     * In accordance with Securities Exchange Act Release No. 39538 (January 12,
     1998), this filing reflects the securities beneficially owned by the
     Private Clients and Asset Management business group ("PCAM") of Deutsche
     Bank AG and its subsidiaries and affiliates (collectively, "DBAG"). This
     filing does not reflect securities, if any, beneficially owned by any other
     business group of DBAG. Consistent with Rule 13d-4 under the Securities
     Exchange Act of 1934 ("Act"), this filing shall not be construed as an
     admission that PCAM is, for purposes of Section 13(d) under the Act, the
     beneficial owner of any securities covered by the filing.



<PAGE>



1. NAME OF REPORTING PERSONS
    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

         Deutsche Asset Management Europe GmbH

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
        (A) [ ]
        (B) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

    Federal Republic of Germany

NUMBER OF         5.       SOLE VOTING POWER
SHARES                     1,362,400
BENEFICIALLY      6.       SHARED VOTING POWER
OWNED BY                   0
EACH              7.       SOLE DISPOSITIVE POWER
REPORTING                  1,362,400
PERSON WITH       8.       SHARED DISPOSITIVE POWER
                           189,000

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,362,400

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
      SHARES [ ]

11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

        2.5%

12. TYPE OF REPORTING PERSON

         IC, CO










<PAGE>



1. NAME OF REPORTING PERSONS
    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

         Deutsche Bank Trust Company Americas

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
        (A) [ ]
        (B) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

NUMBER OF         5.       SOLE VOTING POWER
SHARES                     857,847
BENEFICIALLY      6.       SHARED VOTING POWER
OWNED BY                   9,999
EACH              7.       SOLE DISPOSITIVE POWER
REPORTING                  1,319,518
PERSON WITH       8.       SHARED DISPOSITIVE POWER
                           0

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,319,518

10.    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
       SHARES [ ]

11.    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         2.4%

12. TYPE OF REPORTING PERSON

         BK, CO










<PAGE>




1. NAME OF REPORTING PERSONS
    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

         Deutsche Investment Management Americas Inc.

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
        (A) [ ]
        (B) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

NUMBER OF         5.       SOLE VOTING POWER
SHARES                     271,700
BENEFICIALLY      6.       SHARED VOTING POWER
OWNED BY                   0
EACH              7.       SOLE DISPOSITIVE POWER
REPORTING                  48,200
PERSON WITH       8.       SHARED DISPOSITIVE POWER
                          223,500

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         271,700

10.     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
        SHARES [ ]

11.     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         0.5%

12. TYPE OF REPORTING PERSON

         IA, CO











<PAGE>




1. NAME OF REPORTING PERSONS
    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

         Deutsche Asset Management Group Ltd, London

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
        (A) [ ]
        (B) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

    United Kingdom

NUMBER OF         5.       SOLE VOTING POWER
SHARES                     179,800
BENEFICIALLY      6.       SHARED VOTING POWER
OWNED BY                   0
EACH              7.       SOLE DISPOSITIVE POWER
REPORTING                  179,800
PERSON WITH       8.       SHARED DISPOSITIVE POWER
                           0

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         179,800

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
      SHARES [ ]

11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         0.3%

12. TYPE OF REPORTING PERSON

         IA, CO










<PAGE>





Item 1(a).        Name of Issuer:

                  Isis Pharmaceuticals, Inc.  ("the Issuer")

Item 1(b).        Address of Issuer's Principal Executive Offices:

                  The address of the Issuer's principal executive offices is:

                  2292 Faraday Avenue Carlsbad, CA 92008

Item 2(a).        Name of Person Filing:

                  This statement is filed on behalf of Deutsche Bank AG,
                  ("Reporting Person").

Item 2(b).        Address of Principal Business Office or, if none, Residence:

                  The principal place of business of the Reporting Person is:

                           Taunusanlage 12, D-60325
                           Frankfurt am Main
                           Federal Republic of Germany

Item 2(c).        Citizenship:

                  The citizenship of the Reporting Person is set forth on the
                  cover page.

Item 2(d).        Title of Class of Securities:

                  The title of the securities is common stock, $0.001 par value
                  ("Common Stock").

Item 2(e).        CUSIP Number:

                  The CUSIP number of the Common Stock is set forth on the cover
                  page.

Item 3.           If this statement is filed pursuant to Rules 13d-1(b), or

                  13d-2(b) or (c), check whether the person filing is a:

                 (a) [ ] Broker or dealer registered under section 15 of the
                     Act;

                 (b) [X ] Bank as defined in section 3(a)(6) of the Act;

                                 Deutsche Bank Trust Company Americas

                  (c) [ ]Insurance Company as defined in section 3(a)(19) of the
                      Act;

                  (d) [ X ] Investment Company registered under section 8
                      of the Investment Company Act of 1940;

                        Deutsche Asset Management Group Ltd, London

                  (e) [ X ] An investment adviser in accordance with Rule
                       13d-1(b)(1)(ii)(E);

                          Deutsche Investment Management Americas Inc.

                          Deutsche Asset Management Europe GmbH

                 (f)   [ ] An employee benefit plan, or endowment fund in
                       accordance with Rule 13d-1 (b)(1)(ii)(F);

                 (g)   [X ] parent holding company or control person in
                       accordance with Rule 13d-1 (b)(1)(ii)(G);

                       Deutsche Bank AG

                 (h)  [ ] A savings association as defined in section
                       3(b) of the Federal Deposit Insurance Act;

                 (i)   [ ] A church plan that is excluded from the
                       definition of an investment company under section
                       3(c)(14) of the Investment Company Act of 1940;

                 (j) [ ] Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).


Item 4.           Ownership.

           (a)    Amount beneficially owned:

                  The Reporting Person owns the amount of the Common Stock as
                  set forth on the cover page.

           (b)    Percent of class:

                  The Reporting Person owns the percentage of the Common Stock
                  as set forth on the cover page.

           (c)    Number of shares as to which such person has:



                           (i) sole power to vote or to direct the vote:

                           The Reporting Person has the sole power to vote or
                           direct the vote of the Common Stock as set forth on
                           the cover page.

                           (ii) shared power to vote or to direct the vote:

                           The Reporting Person has the shared power to vote or
                           direct the vote of the Common Stock as set forth on
                           the cover page.

                           (iii) sole power to dispose or to direct the
                           disposition of:

                           The Reporting Person has the sole power to dispose or
                           direct the disposition of the Common Stock as set
                           forth on the cover page.

                           (iv) shared power to dispose or to direct the
                           disposition of:

                           The Reporting Person has the shared power to dispose
                           or direct the disposition of the Common Stock as set
                           forth on the cover page.

Item 5.           Ownership of Five Percent or Less of a Class.

                                 Not applicable.


Item 6.           Ownership of More than Five Percent on Behalf of Another 
                  Person.

                                 Not applicable.

Item 7.           Identification and Classification of the Subsidiary Which 
                  Acquired the Security Being Reported on by the Parent Holding 
                  Company.

                  Subsidiary                              Item 3 Classification

         Deutsche Bank Trust Company Americas               Bank

         Deutsche Investment Management Americas Inc.       Investment Advisor

         Deutsche Asset Management Europe GmbH              Investment Company

         Deutsche Asset Management Group Ltd, London        Investment Company



Item 8.           Identification and Classification of Members of the Group.

                                 Not applicable.

Item 9.           Notice of Dissolution of Group.

                                 Not applicable.

Item 10. Certification.

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.



                            SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                     DEUTSCHE BANK AG


                     By: /s/ Jeffrey A. Ruiz
                     Name: Jeffrey A. Ruiz
                     Title: Vice President


                     By: /s/ Margaret M. Adams
                     Name: Margaret M. Adams
                     Title: Director





Dated: 2/13/03










<PAGE>




                             SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                   Deutsche Asset Management Europe Gmbh

                   By: /s/ Michaela Bundschuh
                   Name: Michaela Bundschuh
                   Title: Head of Global Position Monitoring


                   By: /s/ Susan Seidel
                   Name: Susan Seidel
                   Title: Vice President




Dated: 2/13/03




























<PAGE>






                             SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                    Deutsche Bank Trust Company Americas


                    By: /s/ James T. Byrne, Jr.
                    Name: James T. Byrne, Jr.
                    Title: Secretary






Dated: 2/13/03






























<PAGE>






                                 SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

              Deutsche Investment Management Americas Inc.


              By: /s/ William G. Butterly III
              Name: William G. Butterly III
              Title: Secretary






Dated: 2/13/03





























<PAGE>







                                   SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                Deutsche Asset Management Group Ltd, London

               By: /s/ Patrick Galligan
               Name: Patrick Galligan
               Title: Director


               By: /s/ Hugh Male
               Name: Hugh Male
               Title: Vice President




Dated: 2/13/03