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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 6)*
ISIS PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock
- --------------------------------------------------------------------------------
(Title of Class of Securities)
464330 0 10 9
-------------------------------------------
(CUSIP Number)
Check the following box if a fee is being paid with this statement |_|. (A fee
is not required only if the filing person: (1) has a previous statement on file
reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7).
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page 1 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 2 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | BESSEMER VENTURE PARTNERS II L.P. ("Bessemer II") |
| | 13-3174238 |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |X| |
| | (b) |_| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 759,566 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 759,566 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 759,566 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 2.9% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | PN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 2 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 3 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | DEER II & CO. LLC ("Deer II")* |
| | 13-3174240 |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |X| |
| | (b) |_| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 759,566 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 759,566 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 759,566 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 2.9% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | PN |
- --------------------------------------------------------------------------------
*The shares reported on this page are the same as those reported on page 2 as
Deer II & Co. LLC is the General Partner of Bessemer II.
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 3 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 4 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | BESSEMER VENTURE PARTNERS III L.P. ("Bessemer III") |
| | 11-3197697 |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |X| |
| | (b) |_| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 770,124 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 770,124 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 770,124 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 2.9% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | PN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 4 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 5 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | DEER III & CO. LLC ("Deer III")* |
| | 11-3197696 |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |X| |
| | (b) |_| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 770,124 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 770,124 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 770,124 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 2.9% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | PN |
- --------------------------------------------------------------------------------
*The shares reported on this page are the same as those reported on page 4 as
Deer III & Co. LLC is the General Partner of Bessemer III.
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 5 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 6 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | NEILL H. BROWNSTEIN |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 74,073 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 74,073 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 74,073 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.28% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 6 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 7 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | ROBERT H. BUESCHER |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 9,217 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 9,217 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 9,217 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.03% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 7 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 8 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | WILLIAM T. BURGIN |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 104,859 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 104,859 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 104,859 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.4% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 8 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 9 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | G. FELDA HARDYMON |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 34,557 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 34,557 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 34,557 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.13% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 9 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 10 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | CHRISTOPHER F. O. GABRIELI |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 163,062 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 163,062 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 163,062 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.6% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 10 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 11 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | MICHAEL I. BARACH |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 1,449 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 1,449 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 1,449 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.01% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 11 of 16 pages
- ------------------------------- -------------------------------
|CUSIP No. 464330 0 10 9 | 13G | Page 12 of 16 Pages |
- ------------------------------- -------------------------------
- --------------------------------------------------------------------------------
| 1 | NAME OF REPORTING PERSON |
| | S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | |
| | DAVID J. COWAN |
| | ###-##-#### |
- --------------------------------------------------------------------------------
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| | (a) |_| |
| | (b) |X| |
| | |
- --------------------------------------------------------------------------------
| 3 | SEC USE ONLY |
| | |
| | |
- --------------------------------------------------------------------------------
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
- --------------------------------------------------------------------------------
| | 5 | SOLE VOTING POWER |
| NUMBER OF | | |
| | | 1,000 shs. |
| SHARES | | |
| --------------------------------------------------------------
| BENEFICIALLY | 6 | SHARED VOTING POWER |
| | | |
| OWNED BY | | -0- |
| | | |
| EACH --------------------------------------------------------------
| | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | |
| | | 1,000 shs. |
| PERSON | | |
| --------------------------------------------------------------
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | |
| | | -0- |
- --------------------------------------------------------------------------------
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 1,000 shs. |
- --------------------------------------------------------------------------------
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES |
| | CERTAIN SHARES* |
| | |
| | |_| |
- --------------------------------------------------------------------------------
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 |
| | |
| | 0.00% |
- --------------------------------------------------------------------------------
| 12 | TYPE OF REPORTING PERSON* |
| | |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 12 of 16 pages
Item 1.
(a) Name of Issuer:
ISIS Pharmaceuticals, Inc.
(b) Address of Issuer's Principal Executive Office:
2280 B Faraday Avenue
Carlsbad, California 92008
Item 2.
(a), (b) and (c) Name of Persons Filing, Address of Principal Business
-----------------------------------------------------
Office and Citizenship:
-----------------------
This statement is filed by Bessemer Venture Partners II L.P.
and Bessemer Venture Parnters III L.P. (collectively referred to as "Bessemer"),
both Delaware limited partnerships having their principal office at 1025 Old
Country Road, Suite 205, Westbury, New York, 11590. Bessemer's principal
business is making venture capital investments for its own account and is
carried on at its principal office.
This statement is also filed by Deer II & Co. LLC, a Delaware
limited liability company whose members are Neill H. Brownstein*, Robert H.
Buescher, William T. Burgin, G. Felda Hardymon and Christopher F. O. Gabrieli,
and by Deer III & Co. LLC, a Delaware limited liability company whose members
are Neill H. Brownstein*, Robert H. Buescher, William T. Burgin, G. Felda
Hardymon, Christopher F. O. Gabrieli, Michael I. Barach** and David J. Cowan.
All of such individuals are United States citizens. This statement is also filed
by each of such individuals. Deer II & Co. LLC and Deer III & Co. LLC are,
respectively, the General Partners of Bessemer Venture Partners II L.P. and
Bessemer Venture Partners III L.P. and have their principal offices at the same
address as Bessemer. The principal business of Deer II & Co. LLC and Deer III &
Co. LLC is making venture capital investments for the account of Bessemer and is
carried on at their principal offices, at 535 Middlefield Road, Suite 245, Menlo
Park, California 94025 and at 83 Walnut Street, Wellesley Hills, Massachusetts
02181-2101. Mr. Brownstein's and Mr. Cowan's principal business address is the
Menlo Park address. Mr. Buescher's principal business address is the principal
office of Bessemer. Mr. Burgin's Mr. Hardymon's, Mr. Gabrieli's and Mr. Barach's
principal business address is the Wellesley Hills address.
*As of January 1, 1995 Mr. Brownstein became a special member of Deer II and
Deer III with no power to participate in the management of their affairs.
**As of August 1, 1996, Mr. Barach became a special member of Deer III with no
power to participate in the management of its affairs.
(d) Title of Class of Securities:
Common Stock
(e) CUSIP Number:
464330 0 10 9
Page 13 of 16 pages
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), check
whether the person filing is a:
Not applicable.
Item 4. Ownership as of December 31, 1995
Items 5 through 9 of Pages 2 through 12 of this Statement
incorporated herein by reference.
Item 5. Ownership of Five Percent or Less of a Class
Not applicable.
Item 6. Ownership of More than Five Percent on Behalf of Another Person
Not applicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company
Not applicable.
Item 8. Identification and Classification of Members of the Group
See the answer to Item 2(a), (b) and (c).
Item 9. Notice of Dissolution of Group
Not applicable.
Page 14 of 16 pages
Item 10. Certification
Not applicable.
SIGNATURES
After reasonable inquiry and to the best of our knowledge and
belief, we certify that the information set forth in this statement is true,
complete and correct.
Dated: February 12, 1998
BESSEMER VENTURE PARTNERS II L.P.
By: Deer II & Co. LLC, General Partner
By: /s/ Robert H. Buescher
----------------------------------------
Robert H. Buescher, Manager
DEER II & CO. LLC
By: /s/ Robert H. Buescher
----------------------------------------
Robert H. Buescher, Manager
BESSEMER VENTURE PARTNERS III L.P.
By: Deer III & Co. LLC, General Partner
By: /s/ Robert H. Buescher
----------------------------------------
Robert H. Buescher, Manager
DEER III & CO. LLC
By: /s/ Robert H. Buescher
----------------------------------------
Robert H. Buescher, Manager
NEILL H. BROWNSTEIN
By: *
----------------------------------------
Robert H. Buescher, Attorney-in-Fact
Page 15 of 16 pages
WILLIAM T. BURGIN
By: *
----------------------------------------
Robert H. Buescher, Attorney-in-Fact
G. FELDA HARDYMON
By: *
----------------------------------------
Robert H. Buescher, Attorney-in-Fact
CHRISTOPHER F.O. GABRIELI
By: *
----------------------------------------
Robert H. Buescher, Attorney-in-Fact
MICHAEL I. BARACH
By: *
----------------------------------------
Robert H. Buescher, Attorney-in-Fact
DAVID J. COWAN
By: *
----------------------------------------
Robert H. Buescher, Attorney-in-Fact
/s/ Robert H. Buescher
----------------------------------------
Robert H. Buescher for himself and as
Attorney-in-Fact for the above parties
having an asterisk (*) above their
signature line
Page 16 of 16 pages