0000874015 2021-04-06 2021-04-06 false DE 0000874015 NASDAQ 8-K 2021-04-06 IONIS PHARMACEUTICALS, INC. 000-19125 33-0336973 2855 Gazelle Court Carlsbad CA 92010 760 931-9200 false false false false Common Stock, $.001 Par Value IONS false