Ionis antisense medicine being evaluated in an investigator-initiated clinical study of COVID-19 patients in Brazil
IONIS-PKK-LRx is designed to inhibit bradykinin signaling by halting synthesis of prekallikrein (PKK), a precursor of the enzyme kallikrein, which is involved in the formation of bradykinin, a protein that promotes inflammation and dilates blood vessels. There is growing evidence that the pulmonary edema (fluid in the lungs) and associated morbidities in severe COVID-19, such as the respiratory distress syndrome, are, in part, caused by a dysregulation in bradykinin signaling, referred to as a "bradykinin storm". A therapy that prevents or reduces this bradykinin storm could potentially decrease the number of severe cases of COVID-19 in
"Bradykinin elevations in the body can cause blood vessels to become leaky, causing inflammation in the surrounding tissue. In the lungs, this is often associated with severe COVID-19 cases. We are hopeful that IONIS-PKK-LRx can alleviate some of the worst symptoms caused by the infection and we look forward to seeing data from the study," said
In the study, a single dose of IONIS-PKK-LRx or placebo will be administered subcutaneously to hospital patients who present with symptoms consistent with COVID-19. The primary endpoint is the number of days alive and free of oxygen support up to 15 days.
Learn more about the Phase 2 study here: Antisense Therapy to Block the Kallikrein-kinin Pathway in COVID-19 (ASKCOV).
IONIS-PKK-LRx is also undergoing a Phase 2 clinical study in patients with hereditary angioedema (HAE). In September, the
IONIS-PKK-LRx is one of 20 potentially transformative antisense programs in the growing Ionis-owned pipeline that the company is prioritizing and preparing for commercialization.
IONIS-PKK-LRx is an investigational antisense medicine designed to reduce the production of prekallikrein, or
Ionis' Forward-looking Statement
This press release includes forward-looking statements regarding Ionis' business and the therapeutic potential of IONIS-PKK-LRx. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended
In this press release, unless the context requires otherwise, "Ionis," "Company," "we," "our," and "us" refers to
As the leader in RNA-targeted drug discovery and development, Ionis has created an efficient, broadly applicable drug discovery platform called antisense technology that can treat diseases where no other therapeutic approaches have proven effective. Our drug discovery platform has served as a springboard for actionable promise and realized hope for patients with unmet needs. We created the first and only approved treatment for all patients, children and adults with spinal muscular atrophy as well as the world's first RNA-targeted therapeutic approved for the treatment of polyneuropathy in adults with hereditary transthyretin amyloidosis. Our sights are set on all the patients we have yet to reach with a pipeline of more than 40 novel medicines designed to potentially treat a broad range of disease, including neurological, cardio-renal, metabolic, infectious, and pulmonary diseases.
To learn more about Ionis visit www.ionispharma.com or follow us on twitter @ionispharma.
View original content to download multimedia:http://www.prnewswire.com/news-releases/ionis-antisense-medicine-being-evaluated-in-an-investigator-initiated-clinical-study-of-covid-19-patients-in-brazil-301152861.html
Media: Roslyn Patterson, Vice President, Communications, 760-603-4679; Investors: D. Wade Walke, Ph.D., Vice President, Investor Relations, 760-603-2741