Investors & Media

Ownership Profile

Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 20,900,662 14.88 275,564 6/30/19
The Vanguard Group, Inc. 12,856,865 9.15 383,350 6/30/19
Biogen Inc 11,501,153 8.19 -- 3/1/19
ClearBridge Investments, LLC 9,502,032 6.76 3,722 6/30/19
Baillie Gifford & Co. 8,444,249 6.01 -200,102 6/30/19
Bellevue Asset Management AG 7,957,128 5.66 -70,515 6/30/19
Wellington Management Company, LLP 7,658,199 5.45 119,123 6/30/19
BlackRock Institutional Trust Company, N.A. 7,425,310 5.28 444,200 6/30/19
State Street Global Advisors (US) 3,585,679 2.55 1,032,591 6/30/19
Ivy Investment Management Company 3,180,059 2.26 -182,247 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 8,662,533 6.17 91,728 7/31/19
BB Biotech Fd 7,674,470 5.46 -1,066,864 6/30/19
Vanguard Total Stock Market Index Fund 3,528,695 2.51 51,441 8/31/19
Vanguard Small-Cap Index Fund 3,212,184 2.29 -29,180 8/31/19
Ivy Science and Technology Fund 2,918,326 2.08 -172,300 6/30/19
Fidelity Series Growth Company Fund 2,349,804 1.67 42,019 7/31/19
ClearBridge Aggressive Growth Fund 2,342,745 1.67 -205,000 6/30/19
Fidelity Select Biotechnology Portfolio 2,066,877 1.47 -373,700 7/31/19
Hartford MidCap Fund 2,022,646 1.44 -5,102 7/31/19
Vanguard Extended Market Index Fund 2,015,117 1.43 46,455 8/31/19

* Insider values reflect direct beneficial ownership.

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