Investors & Media

Ownership Profile

Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 20,900,662 14.88 275,564 6/30/19
The Vanguard Group, Inc. 12,856,865 9.15 383,350 6/30/19
Biogen Inc 11,501,153 8.19 -- 3/1/19
ClearBridge Investments, LLC 9,502,032 6.76 3,722 6/30/19
Baillie Gifford & Co. 8,415,289 5.98 -28,960 9/30/19
Bellevue Asset Management AG 7,957,128 5.66 -70,515 6/30/19
Wellington Management Company, LLP 7,658,199 5.45 119,123 6/30/19
BlackRock Institutional Trust Company, N.A. 6,963,930 4.95 -461,380 9/30/19
State Street Global Advisors (US) 3,585,679 2.55 1,032,591 6/30/19
Ivy Investment Management Company 3,180,059 2.26 -182,247 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 8,675,981 6.17 40,898 9/30/19
BB Biotech Fd 7,994,955 5.68 320,485 9/30/19
Vanguard Total Stock Market Index Fund 3,539,939 2.52 11,244 9/30/19
Vanguard Small-Cap Index Fund 3,166,965 2.25 -45,219 9/30/19
Ivy Science and Technology Fund 2,918,326 2.07 -- 9/30/19
Fidelity Series Growth Company Fund 2,361,185 1.68 -- 9/30/19
ClearBridge Aggressive Growth Fund 2,306,791 1.64 -35,954 9/30/19
Hartford MidCap Fund 2,264,300 1.61 231,326 9/30/19
Fidelity Select Biotechnology Portfolio 1,883,577 1.34 -81,900 9/30/19
Vanguard Small-Cap Growth Index Fund 1,876,650 1.33 30,562 9/30/19

* Insider values reflect direct beneficial ownership.

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