Investors & Media

Ownership Profile

Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 20,625,098 14.70 123,948 3/31/19
The Vanguard Group, Inc. 12,473,515 8.89 644,127 3/31/19
Biogen Inc 11,501,153 8.20 -- 3/1/19
ClearBridge Investments, LLC 9,498,310 6.77 -882,009 3/31/19
Baillie Gifford & Co. 8,644,351 6.16 -105,663 3/31/19
Bellevue Asset Management AG 8,027,643 5.72 -1,096,279 3/31/19
Wellington Management Company, LLP 7,539,076 5.37 -87,929 3/31/19
BlackRock Institutional Trust Company, N.A. 6,981,110 4.98 -69,907 3/31/19
Ivy Investment Management Company 3,362,306 2.40 -135,756 3/31/19
First Trust Advisors L.P. 2,591,839 1.85 370,977 3/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 8,741,334 6.23 75,000 12/31/18
Fidelity Growth Company Fund 8,490,936 6.05 251,375 5/31/19
Vanguard Total Stock Market Index Fund 3,463,381 2.47 74,842 6/30/19
Vanguard Small-Cap Index Fund 3,229,595 2.30 -916 6/30/19
Ivy Science and Technology Fund 3,090,626 2.20 -126,900 3/31/19
ClearBridge Aggressive Growth Fund 2,547,745 1.82 -175,000 3/31/19
Fidelity Select Biotechnology Portfolio 2,524,877 1.80 -- 5/31/19
Fidelity Series Growth Company Fund 2,307,785 1.64 17,913 5/31/19
Vanguard Health Care Fund 2,224,908 1.59 105,728 3/31/19
Hartford MidCap Fund 2,027,748 1.45 120,503 5/31/19

* Insider values reflect direct beneficial ownership.

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