Investors & Media

Ownership Profile

Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company LLC 21,172,154 14.99 27,699 9/30/21
The Vanguard Group, Inc. 11,800,009 8.36 -855,820 9/30/21
T. Rowe Price Associates, Inc. 11,737,321 8.31 -521,506 9/30/21
Bellevue Asset Management AG 9,347,926 6.62 -582,319 9/30/21
ARK Investment Management LLC 8,511,384 6.03 -396,349 9/30/21
ClearBridge Investments, LLC 7,327,322 5.19 511,721 9/30/21
BlackRock Institutional Trust Company, N.A. 6,648,842 4.71 -240 9/30/21
State Street Global Advisors (US) 3,521,314 2.49 290,363 9/30/21
Camber Capital Management LP 2,500,000 1.77 500,000 9/30/21
Geode Capital Management, L.L.C. 1,772,767 1.26 10,227 9/30/21

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 9,112,973 6.45 946,011 9/30/21
ARK Genomic Revolution ETF 8,524,176 6.04 44,346 10/31/21
Fidelity Growth Company Fund 7,890,483 5.59 -31,405 9/30/21
T. Rowe Price Mid-Cap Growth Fund 3,708,700 2.63 -3,300 9/30/21
Vanguard Total Stock Market Index Fund 3,412,791 2.42 3,214 10/31/21
Vanguard Small-Cap Index Fund 2,997,632 2.12 11,694 10/31/21
ClearBridge Aggressive Growth Fund 2,086,537 1.48 -220,254 9/30/21
Vanguard Extended Market Index Fund 1,897,599 1.34 3,430 10/31/21
Vanguard Small-Cap Growth Index Fund 1,884,323 1.33 -1,570 10/31/21
First Trust NYSE Arca Biotechnology Index Fund 1,697,209 1.20 36,910 10/31/21

* Insider values reflect direct beneficial ownership.

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