Investors & Media

Ownership Profile

Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company LLC 21,291,159 14.99 21,599 9/30/22
The Vanguard Group, Inc. 12,783,239 9.00 605,747 9/30/22
T. Rowe Price Investment Management, Inc. 11,156,695 7.85 3,320,833 9/30/22
Bellevue Asset Management AG 9,463,400 6.66 -313,128 9/30/22
BlackRock Institutional Trust Company, N.A. 6,992,454 4.92 -12,554 9/30/22
ClearBridge Investments, LLC 5,773,892 4.06 -231,926 9/30/22
T. Rowe Price Associates, Inc. 4,661,606 3.28 -147,164 9/30/22
State Street Global Advisors (US) 3,760,955 2.65 -441,919 9/30/22
ARK Investment Management LLC 3,713,107 2.61 -988,190 9/30/22
BVF Partners L.P. 2,872,953 2.02 1,596,379 9/30/22

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 9,230,000 6.50 -502,973 9/30/22
Fidelity Growth Company Fund 7,031,049 4.95 -72,278 10/31/22
T. Rowe Price Mid-Cap Growth Fund 4,234,900 2.98 -7,400 9/30/22
Vanguard Total Stock Market Index Fund 3,841,589 2.70 13,226 10/31/22
Vanguard Small-Cap Index Fund 3,296,338 2.32 52,873 10/31/22
ARK Genomic Revolution ETF 3,205,329 2.26 -507,318 10/31/22
ClearBridge Aggressive Growth Fund 2,086,537 1.47 -- 9/30/22
Fidelity Series Growth Company Fund 2,070,504 1.46 -- 10/31/22
Vanguard Extended Market Index Fund 1,936,449 1.36 24,715 10/31/22
Fidelity Growth Company K6 Fund 1,917,952 1.35 30,621 10/31/22

* Insider values reflect direct beneficial ownership.

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