Investors & Media

Ownership Profile

Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 20,922,684 14.87 22,022 9/30/19
The Vanguard Group, Inc. 12,214,475 8.68 -642,390 9/30/19
Biogen Inc 11,501,153 8.19 -- 3/1/19
ClearBridge Investments, LLC 9,290,924 6.61 -211,108 9/30/19
Baillie Gifford & Co. 8,415,289 5.98 -28,960 9/30/19
Bellevue Asset Management AG 8,321,914 5.92 364,786 9/30/19
Wellington Management Company, LLP 7,745,339 5.51 87,140 9/30/19
BlackRock Institutional Trust Company, N.A. 6,963,930 4.95 -461,380 9/30/19
State Street Global Advisors (US) 3,650,783 2.60 65,104 9/30/19
Ivy Investment Management Company 3,180,078 2.26 19 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 8,291,214 5.89 -384,767 10/31/19
BB Biotech Fd 7,994,955 5.68 320,485 9/30/19
Vanguard Total Stock Market Index Fund 3,546,542 2.52 6,603 10/31/19
Vanguard Small-Cap Index Fund 3,171,342 2.25 4,377 10/31/19
Ivy Science and Technology Fund 2,918,326 2.07 -- 9/30/19
Hartford MidCap Fund 2,598,318 1.85 334,018 10/31/19
Fidelity Series Growth Company Fund 2,440,934 1.74 79,749 10/31/19
ClearBridge Aggressive Growth Fund 2,306,791 1.64 -35,954 9/30/19
Vanguard Small-Cap Growth Index Fund 1,888,232 1.34 11,582 10/31/19
Fidelity Select Biotechnology Portfolio 1,830,177 1.30 -53,400 10/31/19

* Insider values reflect direct beneficial ownership.

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