"We look forward to continuing the development of IONIS-FXIRx with Bayer. IONIS-FXIRx was the first antithrombotic in development to demonstrate the potential to separate antithrombotic activity from bleeding risk. We recently completed a Phase 2 study in patients with end-stage renal disease on hemodialysis, in which IONIS-FXIRx demonstrated robust reductions in FXI activity and no treatment-related major bleeding," said
Under the agreement, Ionis plans to conduct a Phase 2b study evaluating IONIS-FXIRx in approximately 200 patients with end-stage renal disease on hemodialysis to finalize dose selection. Additionally, Ionis plans to rapidly develop IONIS-FXI-LRx through Phase 1. Following these Ionis-conducted studies and Bayer's decision to further advance these programs, Bayer will be responsible for all subsequent global clinical development activities as well as worldwide regulatory and commercialization activities for both drugs. Ionis is eligible to receive additional milestone payments as each drug advances toward the market. Ionis is also eligible to receive tiered royalties in the low to high twenty percent range on gross margins of both drugs combined.
ABOUT IONIS-FXIRx and IONIS-FXI-LRx
IONIS-FXIRx and IONIS-FXI-LRx are antisense drugs designed to reduce the production of Factor XI. Factor XI is a clotting factor produced in the liver that is an important component of the coagulation pathway. High levels of Factor XI increase the risk of thrombosis, a process involving aberrant blood clot formation that can be responsible for heart attacks and strokes. People who are deficient in Factor XI have a lower incidence of thromboembolic events with minimal increase in bleeding risk. Factor XI deficiency results in a lower incidence of thromboembolic events with minimal increase in bleeding risk.
Ionis' proprietary LIgand Conjugated Antisense, or LICA, technology conjugates specific chemical structures or molecules to antisense drugs to increase the efficiency of drug uptake in a particular tissue and increasing drug potency from 20 to over 30 fold compared to non-conjugated antisense drugs. Currently, Ionis has multiple drugs in their pipeline that contain Ionis' most advanced liver-targeting conjugate, an N-acetyl galactosamine, or GalNAc molecule that interact specifically with receptors present on the surface of important liver cells, which increases uptake of the antisense drug in these cells. The higher potency of Ionis' LICA drugs, compared to their non-LICA forms, enables lower and less frequent doses to be used in patients, which has the potential to reduce side effects and improve patient convenience.
Ionis is the leading company in RNA-targeted drug discovery and development focused on developing drugs for patients who have the highest unmet medical needs, such as those patients with severe and rare diseases. Using its proprietary antisense technology, Ionis has created a large pipeline of first-in-class or best-in-class drugs, with over three dozen drugs in development. SPINRAZA™ (nusinersen) is a drug that has been approved in the U.S. for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients. Biogen is responsible for commercialization of SPINRAZA. Drugs currently in Phase 3 development include volanesorsen, a drug Ionis is developing and plans to commercialize through its wholly owned subsidiary, Akcea Therapeutics, to treat patients with either familial chylomicronemia syndrome or familial partial lipodystrophy; and IONIS-TTRRx, a drug Ionis is developing with GSK to treat patients with TTR amyloidosis. Ionis' patents provide strong and extensive protection for its drugs and technology. Additional information about Ionis is available at www.ionispharma.com.
IONIS' FORWARD-LOOKING STATEMENT
This press release includes forward-looking statements regarding Ionis' alliance with Bayer, the development, activity, therapeutic potential, commercial potential and safety of IONIS-FXIRx and IONIS-FXI-LRx. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended
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Ionis Pharmaceuticals Investor and Media Contact, D. Wade Walke, Ph.D., Vice President, Corporate Communications and Investor Relations, 760-603-2741