Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 18,819,457 13.71 17,575 6/30/18
Biogen Idec Inc 11,501,153 8.38 11,501,153 6/5/18
ClearBridge Investments, LLC 10,920,109 7.95 -64,709 3/31/18
The Vanguard Group, Inc. 10,375,396 7.56 269,184 3/31/18
Wellington Management Company, LLP 9,953,942 7.25 -943,091 3/31/18
Baillie Gifford & Co. 9,279,730 6.76 3,017,079 6/30/18
Bellevue Asset Management AG 8,988,920 6.55 160,400 6/30/18
BlackRock Institutional Trust Company, N.A. 6,472,787 4.72 -119,818 6/30/18
Waddell & Reed Investment Management Company 4,530,100 3.30 -- 3/31/18
State Street Global Advisors (US) 2,965,247 2.16 212,705 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 8,666,334 6.31 150,000 6/30/18
Fidelity Growth Company Fund 7,384,973 5.38 -6,807 6/30/18
Ivy Science and Technology Fund 4,180,000 3.05 -- 6/30/18
Vanguard Total Stock Market Index Fund 3,129,307 2.28 47,455 6/30/18
Vanguard Small-Cap Index Fund 3,117,941 2.27 133,818 6/30/18
Hartford MidCap Fund 2,871,150 2.09 135,767 6/30/18
ClearBridge Aggressive Growth Fund 2,722,745 1.98 -55,107 6/30/18
Fidelity Select Biotechnology Portfolio 2,524,877 1.84 -- 6/30/18
Vanguard Health Care Fund 2,119,180 1.54 -- 3/31/18
Fidelity Series Growth Company Fund 2,104,782 1.53 -- 6/30/18

* Insider values reflect direct beneficial ownership.

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