Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 18,586,234 14.95 32,414 6/30/17
ClearBridge Investments, LLC 11,827,881 9.51 -45,298 6/30/17
Wellington Management Company, LLP 10,502,010 8.45 1,141,457 6/30/17
The Vanguard Group, Inc. 9,855,160 7.93 417,364 6/30/17
Bellevue Asset Management AG 7,578,657 6.09 -87,891 6/30/17
Baillie Gifford & Co. 7,448,380 5.99 -366,417 6/30/17
BlackRock Institutional Trust Company, N.A. 6,506,942 5.23 230,410 6/30/17
Waddell & Reed Investment Management Company 5,140,200 4.13 -10,400 6/30/17
State Street Global Advisors (US) 2,963,990 2.38 -376,481 6/30/17
OppenheimerFunds, Inc. 2,733,518 2.20 10,418 6/30/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 7,630,214 6.14 48,369 8/31/17
Vanguard Total Stock Market Index Fund 2,919,931 2.35 75,624 8/31/17
Vanguard Small-Cap Index Fund 2,878,282 2.31 492 8/31/17
ClearBridge Aggressive Growth Fund 2,790,570 2.24 -14,763 6/30/17
Fidelity Select Biotechnology Portfolio 2,570,377 2.07 -- 8/31/17
Hartford MidCap Fund 2,557,670 2.06 74,601 8/31/17
Ivy Science and Technology Fund 2,556,600 2.06 -22,000 6/30/17
Vanguard Health Care Fund 2,397,300 1.93 -- 6/30/17
Fidelity Series Growth Company Fund 2,233,882 1.80 -102,800 8/31/17
Waddell & Reed Advisors Science and Technology Fund 2,222,700 1.79 79,700 6/30/17

* Insider values reflect direct beneficial ownership.

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