Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 18,710,725 14.92 66,122 12/31/17
ClearBridge Investments, LLC 10,984,818 8.76 -455,033 12/31/17
Wellington Management Company, LLP 10,897,033 8.69 -519,326 12/31/17
The Vanguard Group, Inc. 10,106,212 8.06 162,261 12/31/17
Bellevue Asset Management AG 8,393,040 6.69 265,400 12/31/17
BlackRock Institutional Trust Company, N.A. 6,630,464 5.29 -59,056 12/31/17
Baillie Gifford & Co. 6,262,651 4.99 -349,650 3/31/18
Waddell & Reed Investment Management Company 4,530,100 3.61 -12,000 12/31/17
State Street Global Advisors (US) 2,752,542 2.19 -189,279 12/31/17
OppenheimerFunds, Inc. 2,689,981 2.14 -18,426 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 7,398,267 5.90 -167,819 2/28/18
Vanguard Total Stock Market Index Fund 3,061,392 2.44 58,995 2/28/18
Vanguard Small-Cap Index Fund 2,937,406 2.34 16,190 2/28/18
ClearBridge Aggressive Growth Fund 2,777,852 2.21 -2,777,852 12/31/17
Hartford MidCap Fund 2,690,704 2.14 77,060 2/28/18
Fidelity Select Biotechnology Portfolio 2,524,877 2.01 -- 2/28/18
Ivy Science and Technology Fund 2,214,900 1.77 -35,600 12/31/17
Vanguard Health Care Fund 2,119,180 1.69 -278,120 12/31/17
Fidelity Series Growth Company Fund 2,104,782 1.68 -- 2/28/18
Vanguard Small-Cap Growth Index Fund 1,664,751 1.33 5,647 2/28/18

* Insider values reflect direct beneficial ownership.

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