Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 18,644,603 14.99 58,369 9/30/17
ClearBridge Investments, LLC 11,439,851 9.20 -388,030 9/30/17
Wellington Management Company, LLP 11,416,359 9.18 914,349 9/30/17
The Vanguard Group, Inc. 9,943,951 8.00 88,791 9/30/17
Bellevue Asset Management AG 8,127,640 6.54 548,983 9/30/17
Baillie Gifford & Co. 6,968,149 5.60 -480,231 9/30/17
BlackRock Institutional Trust Company, N.A. 6,689,520 5.38 182,578 9/30/17
Waddell & Reed Investment Management Company 4,542,100 3.65 -598,100 9/30/17
State Street Global Advisors (US) 2,941,821 2.37 -22,169 9/30/17
OppenheimerFunds, Inc. 2,708,407 2.18 -25,111 9/30/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 7,460,814 6.00 -157,300 10/31/17
Vanguard Total Stock Market Index Fund 2,962,480 2.38 10,766 10/31/17
Vanguard Small-Cap Index Fund 2,889,162 2.32 11,783 10/31/17
ClearBridge Aggressive Growth Fund 2,777,852 2.23 -12,718 9/30/17
Hartford MidCap Fund 2,599,575 2.09 11,736 10/31/17
Fidelity Select Biotechnology Portfolio 2,570,377 2.07 -- 10/31/17
Vanguard Health Care Fund 2,397,300 1.93 -- 9/30/17
Ivy Science and Technology Fund 2,250,500 1.81 -306,100 9/30/17
Fidelity Series Growth Company Fund 2,144,882 1.72 -89,000 10/31/17
Waddell & Reed Advisors Science and Technology Fund 1,965,100 1.58 -257,600 9/30/17

* Insider values reflect direct beneficial ownership.

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