Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 18,819,457 13.71 17,575 6/30/18
Biogen Idec Inc 11,501,153 8.38 11,501,153 6/5/18
The Vanguard Group, Inc. 10,933,528 7.96 558,132 6/30/18
ClearBridge Investments, LLC 10,820,120 7.88 -99,989 6/30/18
Baillie Gifford & Co. 9,279,730 6.76 3,017,079 6/30/18
Wellington Management Company, LLP 9,248,361 6.74 -705,581 6/30/18
Bellevue Asset Management AG 8,988,920 6.55 160,400 6/30/18
BlackRock Institutional Trust Company, N.A. 6,472,787 4.72 -119,818 6/30/18
Waddell & Reed Investment Management Company 4,530,100 3.30 -- 6/30/18
State Street Global Advisors (US) 3,059,018 2.23 93,771 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 8,666,334 6.31 150,000 6/30/18
Fidelity Growth Company Fund 7,490,064 5.46 105,091 8/31/18
Ivy Science and Technology Fund 4,180,000 3.05 -- 6/30/18
Vanguard Total Stock Market Index Fund 3,158,160 2.30 28,853 9/30/18
Vanguard Small-Cap Index Fund 3,155,321 2.30 37,380 9/30/18
Hartford MidCap Fund 3,022,518 2.20 151,368 8/31/18
ClearBridge Aggressive Growth Fund 2,722,745 1.98 -55,107 6/30/18
Fidelity Select Biotechnology Portfolio 2,524,877 1.84 -- 8/31/18
First Trust NYSE Arca Biotechnology Index Fund 2,125,724 1.55 1,057,960 9/30/18
Vanguard Health Care Fund 2,119,180 1.54 -- 6/30/18

* Insider values reflect direct beneficial ownership.

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