Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 20,455,239 14.87 1,635,782 9/30/18
Biogen Idec Inc 11,501,153 8.36 11,501,153 6/5/18
The Vanguard Group, Inc. 11,091,298 8.06 157,770 9/30/18
ClearBridge Investments, LLC 10,236,939 7.44 -583,181 9/30/18
Wellington Management Company, LLP 9,295,165 6.76 46,804 9/30/18
Bellevue Asset Management AG 8,976,870 6.53 -12,050 9/30/18
Baillie Gifford & Co. 8,958,113 6.51 -321,617 9/30/18
BlackRock Institutional Trust Company, N.A. 6,874,916 5.00 402,129 9/30/18
Waddell & Reed Investment Management Company 3,832,711 2.79 -697,389 9/30/18
Ivy Investments 3,832,401 2.79 -697,699 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 8,666,334 6.30 -- 9/30/18
Fidelity Growth Company Fund 8,026,778 5.83 19,952 10/31/18
Ivy Science and Technology Fund 3,534,001 2.57 -645,999 9/30/18
Vanguard Total Stock Market Index Fund 3,176,588 2.31 18,428 10/31/18
Vanguard Small-Cap Index Fund 3,163,134 2.30 7,813 10/31/18
Hartford MidCap Fund 2,923,977 2.13 -78,981 10/31/18
ClearBridge Aggressive Growth Fund 2,722,745 1.98 -- 9/30/18
Fidelity Select Biotechnology Portfolio 2,524,877 1.84 -- 10/31/18
Fidelity Series Growth Company Fund 2,135,785 1.55 -51,000 10/31/18
Vanguard Health Care Fund 2,119,180 1.54 -- 9/30/18

* Insider values reflect direct beneficial ownership.

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